Integrated sustainable wastewater treatment with safe reuse of reclaimed water and byproducts in the context of ITS Smart Eco Campus is necessary for realizing a sustainable environment because then only complying with government regulation for wastewater effluent standard is inadequate and must account for the conservation of resources. Considering the high variability and the non-linear nature of wastewater treatment, a smart system is advantageous to be implemented to ensure that consistently high-quality treated water is produced at a lower cost. This research develops a novel approach to wastewater management by integrating web-based server applications with sensor technology, thus involving three aspects of research, i.e., environmental, instrumentation, and ICT.